Laser Pointer / invivo jetPEI
Laser Pointer with every "in vivo-jetPEI with glucose" purchased!
This laser pointer has a blue LED lamp and is perfect for presentations - we will enclose one with every in vivo-jetPEI sold with glucose solution. The offer is valid for all types of in vivo-jetPEI, including in vivo-jetPEI-Man, -Gal, -FluoF, -FluoR and -Biotin. offer valid until 31st December 2007 |
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in vivo-jetPEI:
In vivo JetPEI provides versatile, reproducible and reliable nucleic acid delivery in animals. This linear polyethylenimine reagent is used for: Gene therapy RNA interference Protein function studies Genetic vaccination in vivo-jetPEI is currently used iin human clinical trials as a delivery vector for cancer gene therapy.
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Figure 1. Systemic delivery using in vivo-jetPEI. Bioluminescent imaging of luciferase expression in living Balb/C mouse using a cooled camera 24 h after gene delivery. pCMVLuc (50 µg) was complexed with in vivo-jetPEI in 400 µl of 5% glucose solution and injected into the tail vein. Courtesy J.L. Coll. |
Ligand-conjugated Derivatives
in vivo-jetPEI-Gal:
a galactose-conjugated in-vivo jetPEI designed to target liver cells expressing the asialoglycoprotein receptor, such as hepatocytes.
in vivo-jetPEI-Man:
a mannose-conjugated in-vivo jetPEI designed to target cells expressing mannose-specific membrane receptors, such as macrophages.
Labeled in vivo-jetPEI
in-vivo jetPEI-FluoF:
a fluorescein-conjugated linear polyethylenimine derivative (excitation at 490 nm; emission at 520 nm).
in-vivo jetPEI-FluoR:
a tetramethylrhodamine-conjugated linear polyethylenimine derivative (excitation at 555 nm; emission at 580 nm).
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Figure 2.
Biodistribution of fluorescent complexes in the lungs after intravenous administration . in vivo-jetPEI-FluoR/DNA complexes were injected in the tail vein of C57Bl6 mice. Mice were sacrified 6 hrs after injection and the lungs were collected. Cryosections of the lungs were visualized by fluorescence microscopy (Courtesy J-L Coll). |
in-vivo jetPEI-Biotin
a biotin-conjugated linear polyethylenimine derivative designed to follow biodistribution of jetPEI / DNA complexes using the streptavidin / avidin technology (radiolabeled, enzyme-conjugated or fluorescent avidin) (Dolivet et al 2002, Cancer Gene Therapy:9, 708-714). jetPEI-Biotin is also convenient for developing targeted complexes using the ligand-conjugated avidin (liganded avidin / streptavidin).
in vivo jetPEI with glucose
Cat No |
Description |
Qty |
DNA delivered |
Price
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201-10G |
in vivo jetPEI with Glucose |
0.1ml + 10ml 5%glucose |
0.5-1 mg |
£187
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201-20G |
in vivo jetPEI with Glucose |
0.2ml + 10ml 5%glucose |
1-2 mg |
£326
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201-50G |
in vivo jetPEI with Glucose |
0.5ml + 2 x 10ml 5%glucose |
2.5-5 mg |
£673
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202-10G |
in vivo-jetPEI-Gal with glucose |
0.1ml + 10ml 5%glucose |
0.5-1 mg |
£354
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202-20G |
in vivo-jetPEI-Gal with glucose |
0.2ml + 10ml 5%glucose |
1-2 mg |
£619
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203-10G |
in vivo-jetPEI-Man (mannoseconjugated) with Glucose |
0.1ml + 10ml 5%glucose |
0.5-1 mg |
£354
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203-20G |
in vivo-jetPEI-Man (mannoseconjugated) with Glucose |
0.2ml + 10ml 5%glucose |
1-2 mg |
£619
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205-10G |
in vivo-jetPEI-FluoF labelled with Glucose |
0.1ml + 10ml 5%glucose |
0.5-1 mg |
£269
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206-10G |
in vivo-jetPEI-FluoR labelled with Glucose |
0.1ml + 10ml 5%glucose |
0.5-1 mg |
£269
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207-10G |
in vivo-jetPEI-Biotin labelled with Glucose |
0.1ml + 10ml 5%glucose |
0.5-1 mg |
£269
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Product details |
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Add to basket |
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Datasheet PDF |
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