InvivoGen have developed a high throughput technology to determine whether a compound is recognised by Toll Like Receptors (TLRs). Their method is based on TLR-induced NF-kappa B activation of HEK293 cells.

This service provides a rapid, reliable and cost effective way of screening new molecules which have the ability to stimulate TLRs. Simply send the molecules which you believe are potential TLR ligands and InvivoGen will provide you with a report detailing which products activate TLRs and which TLR is involved. 

• Quick results: in only 2 weeks!
  
• Screening flexibility
  
• Cost effective
  
• Qualitative and quantitative analysis
  
• Confidentiality guaranteed

 

Send the molecules you believe are potential TLR ligands and in less than 2 weeks InvivoGen will provide you with a report detailing which products activate TLRs and which TLRs are involved.

• Activity can be tested on up to seven different Toll Like Receptors: TLR2,3,4,5,7,8, and 9. Other TLRs can be added upon request including mouse TLRs.

• TLR stimulation is tested by assessing NF-kappaB activation in HEK293 cells expressing a given TLR.

• Level of activity of a potential ligand is compared to that of a known ligand for each TLR.

• Results are provided as a detailed report. All procedures are performed according to strict guidelines. Confidentiality is guaranteed.

 

If you are interested in this service (catalogue number tlrl-test) , contact us for further information and a quotation.